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A UK based Emergency Medicine podcast for anyone who works in emergency care. The St Emlyn ’s team are all passionate educators and clinicians who strive to bring you the best evidence based education. Our four pillars of learning are evidence-based medicine, clinical excellence, personal development and the philosophical overview of emergency care. We have a strong academic faculty and reputation for high quality education presented through multimedia platforms and articles. St Emlyn’s is a name given to a fictionalised emergency care system. This online clinical space is designed to allow clinical care to be discussed without compromising the safety or confidentiality of patients or clinicians.
Episodes

Tuesday Dec 13, 2016
Ep 85 - Top tips for chest drains.
Tuesday Dec 13, 2016
Tuesday Dec 13, 2016
Title: Mastering Chest Drains: Essential Tips and Techniques for Emergency Medicine
In this comprehensive guide, Simon Carley and Rick Bodey from St Emlyns explore the essential aspects of chest drains, also known as intercostal drains or chest tubes, focusing on their importance, optimal techniques, and common pitfalls in emergency medicine.
Importance of Chest Drains
Chest drains are critical for managing conditions like pneumothorax, hemothorax, and pleural effusion by removing air, blood, or fluid from the pleural cavity. Despite not being a daily procedure in the UK, proficiency in chest drain insertion is crucial due to the potential for severe complications, including organ damage and infection. Proper training and careful execution are necessary, especially as new technologies and medical practices evolve.
Choosing the Right Size
Traditionally, large-bore drains (32-36 French) were used for pneumothoraces to prevent blockage by clots. However, recent evidence supports the use of smaller drains (28-32 French), even for trauma patients. Smaller drains are less invasive, cause less discomfort, and are equally effective. The move towards smaller drains aligns with a trend in medicine favoring minimally invasive procedures, which reduce patient risk and enhance comfort.
Management of Occult Pneumothoraces
Advances in imaging, like CT scans and ultrasound, have increased the detection of occult pneumothoraces, which are often asymptomatic and not visible on chest x-rays. Traditional guidelines recommended chest drains for all traumatic pneumothoraces, but recent research suggests conservative management may be appropriate in many cases. A systematic review found no significant difference in outcomes between patients with occult pneumothoraces managed conservatively and those who received chest drains. This highlights the importance of assessing each patient's condition, monitoring closely, and only intervening when necessary, particularly in stable, asymptomatic patients.
Optimizing Analgesia
Pain management during chest drain insertion is vital. Traditional local anesthesia methods are often insufficient, especially in trauma settings. Ketamine has emerged as an effective option, providing both analgesia and sedation without significant respiratory depression. Administered in small, incremental doses, ketamine helps manage pain and anxiety, making the procedure more tolerable. Additional analgesics, like fentanyl and midazolam, can complement ketamine, offering a multimodal approach to pain management.
Intra-Pleural Analgesia
Injecting local anesthetics, such as bupivacaine, into the pleural cavity can further enhance patient comfort, particularly as the lung re-expands and contacts the parietal pleura. This method is supported by randomized controlled trials and can significantly reduce pain in the first few hours post-insertion, aiding in better respiratory function and reducing the risk of complications like pneumonia.
Securing the Drain
Properly securing the chest drain is crucial to prevent accidental dislodgement, especially during patient transport or imaging. Techniques like Neil Bandari's "Jo'burg knot" offer reliable methods for securing drains, though simpler techniques may suffice for less frequent practitioners. Transparent dressings are recommended to allow monitoring of the insertion site and ensure the drain remains securely anchored.
The Role of Ultrasound
Ultrasound is an invaluable tool for accurately placing chest drains, particularly in cases of pleural effusion or complex pleural anatomy. It aids in identifying the best insertion site, reducing the risk of complications, and confirming the resolution of pneumothorax. Ultrasound is especially useful in patients with obesity or chronic lung conditions, where traditional landmarks may not be reliable.
Aspiration of Pneumothoraces
For primary spontaneous pneumothoraces, aspiration may be a viable alternative to chest drain insertion, particularly when specific criteria are met. This less invasive approach can be performed with a standard IV cannula or a small Seldinger technique, which also provides a pathway for chest drain insertion if necessary. This method is beneficial in outpatient settings, allowing for quick resolution without hospitalization.
Conclusion
The management of chest drains is a dynamic field, continually evolving with new research and technology. Emergency medicine practitioners must stay informed and adapt to evidence-based practices, including the use of smaller chest drains, conservative management of occult pneumothoraces, optimized analgesia, and the application of ultrasound. The goal is to provide safe, effective, and patient-centered care, minimizing unnecessary interventions.
At St Emlyns, we strive to share knowledge and best practices to enhance patient care. We invite our readers to contribute their insights and experiences, fostering a collaborative approach to improving clinical skills and outcomes in emergency medicine.

Friday Dec 09, 2016
Ep 84 - Critical Appraisal Nugget 4: Intention to Treat
Friday Dec 09, 2016
Friday Dec 09, 2016
Understanding Intention to Treat in Clinical Trials: A Key Concept for Critical Appraisal
Welcome to the St Emlyns podcast! In this episode, Simon Carley and Rick Bodey delve into an essential topic for anyone interested in critical appraisal and clinical trials—Intention to Treat (ITT). This principle is a cornerstone in the analysis of randomized controlled trials (RCTs), crucial for ensuring the validity and applicability of study findings.
What is Intention to Treat (ITT)?
ITT is a methodological principle used in the analysis of data from RCTs. It requires that participants be analyzed in the groups to which they were originally randomized, regardless of whether they adhered to the treatment protocol. This approach helps maintain the benefits of randomization, such as comparability between groups, and provides a more conservative and realistic estimate of a treatment's effectiveness.
The ITT principle is essential because it preserves the randomization process's integrity, ensuring that the groups remain comparable. This comparability helps minimize bias, allowing researchers to attribute differences in outcomes to the interventions rather than to other confounding factors.
Importance of ITT in Clinical Trials
The ITT principle plays a critical role in RCTs by ensuring that the analysis reflects real-world scenarios where patients may not perfectly adhere to treatment regimens. For example, in a trial comparing a new anticoagulant, Carleyoxaban, to warfarin, ITT analysis would include all participants, even those who did not complete the treatment due to side effects. This comprehensive approach provides a more accurate reflection of the treatment's potential benefits and risks in everyday clinical practice.
By including all participants as originally allocated, ITT analysis helps prevent bias introduced by excluding participants who experience adverse effects or switch treatments. This is vital for obtaining a realistic estimate of the treatment's effect, considering real-world complexities such as patient non-compliance.
Challenges and Considerations
While ITT is the gold standard for RCT analysis, it does come with challenges. One significant challenge is that it can obscure the reasons why participants dropped out or switched treatments. These reasons can provide valuable insights into the treatment's tolerability and feasibility. For instance, in the hypothetical trial with Carleyoxaban, understanding why 50% of participants dropped out could highlight serious side effects that might not be evident from an ITT analysis alone.
In some cases, a per-protocol analysis, which includes only those participants who fully adhered to the treatment protocol, can offer additional insights. This type of analysis can help distinguish between a treatment's efficacy (its effect under ideal conditions) and effectiveness (its effect in a typical clinical setting). However, per-protocol analysis can introduce bias by including only those who were more likely to tolerate and benefit from the treatment.
ITT vs. Per-Protocol Analysis
Per-protocol analysis is particularly valuable in certain situations, such as non-inferiority trials. These trials aim to show that a new treatment is not worse than an existing one. In such cases, per-protocol analysis can provide a more conservative estimate, ensuring that observed differences are not due to adherence variations between groups.
For example, in a trial evaluating a new protocol for early discharge of patients with suspected pulmonary embolism, ITT might show no difference in outcomes if many participants did not follow the new protocol. However, a per-protocol analysis could reveal whether the protocol, when followed, led to improved outcomes or safety concerns.
Similarly, in trials assessing new medications, ITT can provide a realistic estimate by accounting for dropouts due to side effects. This is crucial for understanding the medication's overall safety and effectiveness in the general population.
Practical Implications for Clinicians
For clinicians, understanding ITT is essential for interpreting the results of clinical trials. ITT analysis offers a pragmatic view of a treatment's potential benefits and risks, reflecting the complexities of real-world clinical practice. When deciding whether to use a new treatment, clinicians must consider factors like patient adherence and potential side effects, both of which are accounted for in ITT analyses.
Moreover, clinicians should be critical when appraising studies, checking whether ITT principles were followed. This includes examining flow diagrams that show participant allocation and follow-up, ensuring that the number of participants analyzed matches those initially randomized. Such diligence helps ensure that study findings are robust and applicable to clinical practice.
Conclusion and Key Takeaways
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ITT is Essential: It preserves the benefits of randomization and provides a realistic estimate of treatment effects by including all participants as initially allocated.
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Per-Protocol Analysis: While useful in certain contexts, such as non-inferiority trials, it should be interpreted cautiously due to potential biases.
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Real-World Relevance: ITT helps clinicians understand the applicability of trial results in everyday practice, considering issues like non-compliance and side effects.
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Critical Appraisal: Clinicians should always verify if ITT analysis was performed when appraising studies, as it ensures a comprehensive understanding of the treatment's effectiveness.
As we continue to explore critical appraisal and clinical trials, we encourage you to stay tuned to the St Emlyns podcast. Future episodes will delve deeper into various aspects of clinical research, providing valuable insights to enhance your practice. Understanding concepts like ITT not only improves your ability to interpret research but also equips you with the tools to make informed, evidence-based decisions in patient care.
Thank you for joining us in this discussion. The ITT principle is a key component of high-quality RCTs and an essential concept for anyone involved in clinical research or patient care. By mastering this and other critical appraisal tools, you can significantly improve your understanding of medical literature and contribute to better patient outcomes. Stay curious, keep learning, and we'll see you in the next episode of the St Emlyns podcast!